Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom.Patients with

BACKGROUND: Cystic echinococcosis (CE) caused by the Echinococcus granulosus, is a major public health problem worldwide, including India.The different genotypes of E.granulosus responsible for human hydatidosis have been reported from endemic areas throughout the world.However, the genetic characterization of E.granulosus infecting the human popul

Archaeological research in Apulia have given solid grounds for a historical characteristic of the Left Foot Pad region, specifying the nature of settlements and their socio-economic environment in the Roman age.But production centers, primarily pottery workshops, as well as commonly traded shapes, trade routes and consumer centers still are in need

Abstract Background To report a new technique for iris capture of the posterior chamber intraocular lens (IOL) implanted in patients with a posterior capsule defect.Methods In this retrospective case series, Masters of the Universe a rectangular loop ciliary body suture technique was performed to rectify iris capture.The suture passes between the I

Cell-free protein synthesis (CFPS) is an in vitro process that enables diverse applications in research, biomanufacturing, point-of-care diagnostics, therapeutics, and education using minimal laboratory equipment and reagents.One of the major limitations of CFPS implementation is its sensitivity to plasmid type.Specifically, plasmid templates based